Date: Friday, August 16, Time: 10:10 - 10:26, Room: 6B
STRUCTURAL BIOLOGY OF IGSF CELL ADHESION MOLECULES
E. Yvonne Jones yvon@biop.ox.ac.uk
Session Chair: Pamela J. Bjorkman
Division Of Biology
156-29 Howard Hughes Med. Inst
California Inst. Of Technology
Pasadena CA 91125
Phone: 818 395 8350
Fax: 818 395 8351
bjorkman@citray.caltech.edu
Program Contact: I. Wilson
Dept. Of Mol. Biology
The Scripps Research Inst. MB 13
10666 N. Torrey Pines Rd.
La Jolla CA 92307
FAX 619 554 6105
wilson@scripps.edu
(E0837) MS04.15.01
Date: Friday, August 16, Time: 10:10 - 10:26, Room: 6B
STRUCTURAL BIOLOGY OF IGSF CELL ADHESION MOLECULES
E. Yvonne Jones
yvon@biop.ox.ac.uk
(S0819) MS04.15.02
Date: Friday, August 16, Time: 10:26 - 10:37, Room: 6B
THE CRYSTAL STRUCTURE OF ICAM-2, ITS COMPARISON TO OTHER INTEGRIN-BINDING PROTEINS
J.-H. Wang , J. Casasnovas, T. Springer, J.-H. Liu and S.C. Harrison
wang@xta10.harvard.edu
(E1156) MS04.15.03
Date: Friday, August 16, Time: 10:37 - 10:53, Room: 6B
STRUCTURAL STUDIES OF CATALYTIC ANTIBODIES WITH ESTERASE ACTIVITY
M. Knossow , J.-B. Charbonnier, B. Gigant, B. Golinelli, D. Tawfik, Z. Eshhar and B.S. Green
(E0627) MS04.15.04
Date: Friday, August 16, Time: 10:53 - 11:04, Room: 6B
THERAPEUTIC ANTIBODY STRUCTURES OF RAT AND HUMANIZED (CAMPATH-1) Fab FRAGMENTS
Anne C. Bloomer , Graham M. T. Cheetham, Geoffrey Hale and Herman Waldmann
acbl@mrc-lmb.cam.ac.uk
(E0091) MS04.15.05
Date: Friday, August 16, Time: 11:04 - 11:20, Room: 6B
THE ANTI-TUMOR ANTIBODY BR96: X-RAY STRUCTURES IN ANTIGEN-BOUND AND IN FREE FORM
S. Sheriff , C. Chang, P. D. Jeffery and J. Bajorath
sheriff@bms.com
(S0646) MS04.15.06
Date: Friday, August 16, Time: 11:20 - 11:31, Room: 6B
STRUCTURE OF A HUMAN IgM RHEUMATOID FACTOR COMPLEXED WITH ITS AUTOANTIGEN IgG Fc
A.L. Corper , M.K. Sohi, R. Jefferis, M. Steinitz, A. Feinstein, D. Beale, M.J. Taussig and B.J. Sutton
alc@helios.rai.kcl.ac.uk
(E1435) MS04.15.07
Date: Friday, August 16, Time: 11:31 - 11:47, Room: 6B
STRUCTURAL ANALYSIS OF A PROTEIN COMPLEX IN THE IMMUNE SYSTEM
P.J. Bjorkman , M. Raghavan, D.E. Vaughn and W.P. Burmeister
bjorkmanp@starbase1.caltech.edu
(S0301) MS04.15.08
Date: Friday, August 16, Time: 11:47 - 12:03, Room: 6B
CRYSTAL STRUCTURE OF MURINE CD1D1
Ian A. Wilson , Zhonghao Zeng, A. Paul Castano, Brant Segelke, Enrico A. Stura and Per A. Peterson
wilson@scripps.edu
(E1252) MS04.15.09
Date: Friday, August 16, Time: 12:03 - 12:14, Room: 6B
STRUCTURE OF THE MHC CLASS II MOLECULE HLA-DR4/HA306-318 PEPTIDE/SUPERANTIGEN COMPLEX
W.C. Stallings , A.M. Stevens, R.A. Stegeman, M.L. Zacheis, D.A. Kirschmann, T. Witman, X.-T. Fu, R.F. Karr, B.D. Schwartz and S.L. Woulfe
wcstal@ccmail.monsanto.com
(S0817) MS04.15.10
Date: Friday, August 16, Time: 12:14 - 12:30, Room: 6B
STRUCTURE OF A T CELL RECEPTOR BOUND TO A CLASS I MHC-PEPTIDE COMPLEX
David N. Garboczi , Partho Ghosh, Ursula Utz, William E. Biddison and Don C. Wiley
garboczi@crystal harvard.edu
(S0406) PS04.15.11
Session: III, Board: 117, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF MFE-23, A CLINICALLY IMPORTANT ANTI-CEA SCFV ANTIBODY FRAGMENT, AT 028 NM RESOLUTION
M.K. Boehm , A.L. Corper, T. Wan, M. Sohi, B.J. Sutton, J.D. Thornton, P.A. Keep, R.H.J. Begent and S.J. Perkins
mkboehm@rfhsm.ac.uk
(E0876) PS04.15.12
Session: III, Board: 118, Room: Not Yet Assigned
ARE "HOT SPOTS" [SUPER-FLEXIBLE REGIONS] ON THE SURFACE OF AN ANTIGEN ESSENTIAL FOR ANTIGEN-ANTIBODY BINDING?
Gerson H. Cohen and David R. Davies
ghc@vger.niddk.nih.gov
(E0379) PS04.15.13
Session: III, Board: 119, Room: Not Yet Assigned
THE HIGH RESOLUTION STRUCTURE OF AN ANTI-hCG Fab
Constantina Fontinou , Jeremy Beauchamp, Annemarie DeHaan, Ebo Bos and Neil W. Isaacs
dina(chem.gla.ac.uk
(E0658) PS04.15.14
Session: III, Board: 120, Room: Not Yet Assigned
CHARACTERIZATION OF CHEMICALLY SYNTHESIZED HYBRID CXC CHEMOKINES
Tai Y. Fu , Yu Wai Chen, Yaoguang Luo, Ian Clark-Lewis and Gary D. Brayer
tony@laue.biochem.ubc.ca
(S0303) PS04.15.15
Session: III, Board: 121, Room: Not Yet Assigned
STRUCTURAL STUDIES OF CATALYTIC ANTIBODIES
A. Heine , E. A. Sutra, K. D. Janda, C. F. Barbas III, R. A. Lerner and I. A. Wilson
aheine@scripps.edu
(S0362) PS04.15.16
Session: III, Board: 122, Room: Not Yet Assigned
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN KIV LIGHT CHAIN LEN
D.-B. Huang , C. Ainsworth, F.J. Stevens, M. Schiffer and C.H. Chang
huang@anlcmb.bim.anl.gov
(E0493) PS04.15.17
Session: III, Board: 123, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR COMPLEXES WITH ADN INHIBITORY FAB
Mingdong Huang , Rashid J. Syed, Enrico A. Stura, Wolfram Ruf, Thomas S. Edgington and Ian A. Wilson
huangm@scripps.edu
(E0872) PS04.15.18
Session: III, Board: 124, Room: Not Yet Assigned
PRELIMINARY STRUCTURAL FEATURES OF HUMAN HEPARIN BINDING PROTEIN
Lars F. Iversen , Jette S. Kastrup and Ingrid Kjoller Larsen
lars@medchem.dfh.dk
(E0529) PN04.15.19
Date: Not Yet Assigned, Time: Not Yet Assigned, Room: Not Yet Assigned
CRYSTALLIZATION AND PRELIMINARY X-RAY STUDY OF THE VISCUM ALBUM ML1 TOXIN IN ITS NATIVE STATE
N. V. Konareva , A. A. Mikhailov, A.G. Tonevitskii, I.I. Agapov, A.N. Popov and H.D. Bartunik
amm@biostr.crystal.msk.ru
(S0114) PS04.15.20
Session: III, Board: 125, Room: Not Yet Assigned
STRUCTURAL BASIS OF HIV-1 PROTEASE INHIBITION BY A MONOCLONAL ANTIBODY
Julien Lescar , Renata Stouracova, Marie-Madeleine Riottot, Veronique Chitarra, Jiri Brynda, Juraj Sedlacek and Graham Bentley
lescar pasteur.fr
(E1163) PS04.15.21
Session: III, Board: 126, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A (OspA) OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL Fab
Hong Li , John Dunn, Benjamin J. Luft and Catherine L. Lawson
hongli@bnlbio.bio.bnl.gov
(E0593) PS04.15.22
Session: III, Board: 127, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF A CDR3 MUTANT OF AT CELL ANTIGEN RECEPTOR VADOMAIN
Hogmin Li , Marina Lebedeva, Sally Ward and Roy Mariuzza
hmli@indigo19.carb.nist.gov
(S0392) PS04.15.23
Session: III, Board: 128, Room: Not Yet Assigned
CRYSTALLOGRAPHIC STUDIES OF MUTANTS OF THE CHEMOKINE MACROPHAGE INFLAMMATORY PROTEIN-1ALPHA
J. Maclean , N.W. Isaacs and G.J. Graham
johnm@chem.gla.ac.uk
(E1103) PS04.15.24
Session: III, Board: 129, Room: Not Yet Assigned
PRELIMINARY X-RAY DIFFRACTION ANALYSIS OF AN ANTIBODY FRAGMENT AGAINST P-GLYCOPROTEIN
Valerie Monem , Sona Vasudevan, Kathy L. Johns and David R. Rose
vmonem@oci.utoronto.ca
(E0341) PS04.15.25
Session: III, Board: 130, Room: Not Yet Assigned
THE MOLECULAR ARCHITECTURE OF TWO MICROBIAL SUPERANTIGENS
A.C. Papageorgiou , H. S. Tranter, R. D. Brehm and K. R. Acharya
bssacp@midge.bath.ac.uk
(E0233) PS04.15.26
Session: IV, Board: 009, Room: Not Yet Assigned
THE MOLECULAR STRUCTURE OF THE LIPOAMIDE DEHYDROGENASE DOMAIN (DLDH) OF A SURFACE ANTIGEN FROM NEISSERIA MENINGITIDIS
Lucile Pernot , I. nes Li de la Sierra, Thierry Prange, Predo Saludjian, Marc Schiltz, Roger Fourme and Gabriel Padron
lpernot@lure.u-psud.fr
(E0107) PS04.15.27
Session: IV, Board: 010, Room: Not Yet Assigned
THE 25 A STRUCTURE OF FAB JEL42-HPr COMPLEX
L. Prasad , J.S. Lee, E.B. Waygood and L.T.J. Delbaere
prasad@sask.usask.ca
(E0033) PS04.15.28
Session: IV, Board: 011, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF HUMAN INTERFERON-ALPHA 2
Ramaswamy Radhakrishna , Leigh J. Walter, Paul Reichert, Alan Hruza, T. L. Nagabhushan and Mark R. Walter
(E0383) PS04.15.29
Session: IV, Board: 012, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF A MURINE MONOCLONAL ANTI-ELAM IGG1 ANTIBODY 7A9 FAB FRAGMENT
Adela Rodriguez-Romero , Orna Almog, Maria Tordova, Zafar Randawa and Gary L. Gilliland
adela@ibm3.carb.nist.gov
(D0052) PS04.15.30
Session: IV, Board: 013, Room: Not Yet Assigned
A SULFIDE OXIDATION CATALYTIC ANTIBODY
B. D. Santarsiero , L. C. Hsieh-Wilson, P. G. Schultz and R. C. Stevens
bds@neuron1.berkeley.edu
(S0594) PS04.15.31
Session: IV, Board: 014, Room: Not Yet Assigned
METAL-BINDING IN SUPERANTIGENS
E.M. Schad , M. Dohlsten, Per Bjork and L.A. Svensson
(S0353) PS04.15.32
Session: IV, Board: 015, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF THE MHC CLASS IB MOLECULE H2-M3 WITH FOUR DIFFERENT FORMYLATED-PEPTIDES
San Tai Shen , Chyung-Ru Wang, Kirsten Fischer Lindahl and Johann Deisenhofer
santai@chop.swmed.edu
(D0049) PS04.15.33
Session: IV, Board: 016, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF AN AMINO-ACYLATION CATALYTIC ANTIBODY
Ben Spiller , B. D. Santarsiero, Linda Hsieh and Raymond Stevens
bens@mended.berkeley.edu
(E0473) PS04.15.34
Session: IV, Board: 017, Room: Not Yet Assigned
STRUCTURE AND COMPARISON OF HIV-1 GP120 PEPTIDES IN COMPLEX WITH HIV-1 NEUTRALIZING FABS
R. L. Stanfield , J. B. Ghiara, J. M. Rini, E. A. Stura, A. C. Satterthwait and I. A. Wilson
robyn@scripps.edu
(E0895) PS04.15.35
Session: IV, Board: 018, Room: Not Yet Assigned
THE THREE DIMENSIONAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C2 FROM TWO CRYSTAL FORMS
S. Swaminathan , W. Furey, J. Pletcher and M. Sax
swami@vms.cis.pitt.edu
(E0954) PS04.15.36
Session: IV, Board: 019, Room: Not Yet Assigned
CRYSTAL STRUCTURE OF ANTI-P-GLYCOPROTEIN FAB MRK-16 IN COMPLEX WITH ITS PEPTIDE EPITOPE
S. Vasudevan , K. Johns and D.R. Rose
svasudev@oci.utoronto.ca
(S0752) PS04.15.37
Session: IV, Board: 020, Room: Not Yet Assigned
STRUCTURE OF AN IMMUNODOMINANT 38-kDa PROTEIN ANTIGEN b (Pab) FROM MYCOBACTERIUM TUBERCULOSIS
Nand K. Vyas , Meenakshi N. Vyas, Abha Choudhary, Zengyi Chang and Florante A. Quiocho
(D0051) PS04.15.38
Session: IV, Board: 021, Room: Not Yet Assigned
THE CRYSTAL STRUCTURES OF SEVERAL 48G7 CALALYTIC ANTIBODIES WITH ESTROLYTIC ACTIVITY
Gary J. Wedemayer , Leo Wang and Raymond C. Stevens
garywede@neuron1.berkeley.edu
(E1122) PS04.15.39
Session: IV, Board: 022, Room: Not Yet Assigned
CRYSTALLIZATION OF MURINE T-CELL RECEPTORS
D. Williams , A. Heine, E.A. Stura, J. Snook and I.A. Wilson
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